The Effects of Diflubenzuron on Acetylcholinesterase (EC 3.1.1.7) Activity and Liver Ultrastructure in Wistar Rats
نویسندگان
چکیده
Diflubenzuron is a commonly used larvicide/biocidal substance. The present study aimed to reveal the effects of diflubenzuron on Acetylcholinesterase (AChE) enzymatic activity and liver histopathology mammalian species (rats). animals fed with various doses tissues rats were taken 10th, 20th, 25th, 45th days sixth month. AChE was measured by spectrophotometer. Tissues embedded in Araldite 502 (Sigma), took ultrathin sections, examined under 100 CX II Transmission Electron Microscope. chronic dose group like that control group. subacute found be significantly different from After exposure terminated, still lower day compared Chronic caused adverse tissues, such as numerous mitochondria, abnormally structured nuclei hepatocytes many lipid droplets sinusoids ultrastructure. damage observed 20th 25th days, but tissue partly regenerated day. Cellular might recover after 45 probably takes more time reach normal level.
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ژورنال
عنوان ژورنال: Gazi university journal of science
سال: 2023
ISSN: ['2147-1762']
DOI: https://doi.org/10.35378/gujs.868668